An Integrated-Likelihood Method for Estimating Genetic Differentiation Between Populations

An integrated-likelihood method for estimating genetic differentiation between populations.

The aim of this article is to develop an integrated-likelihood (IL) approach to estimate the genetic differentiation between populations. The conventional maximum-likelihood (ML) and pseudolikelihood (PL) methods that use sample counts of alleles may cause severe underestimations of FST, which means overestimations of theta=4Nm, when the number of sampling localities is small. To reduce such bi...

Bayesian analysis of genetic differentiation between populations.

We introduce a Bayesian method for estimating hidden population substructure using multilocus molecular markers and geographical information provided by the sampling design. The joint posterior distribution of the substructure and allele frequencies of the respective populations is available in an analytical form when the number of populations is small, whereas an approximation based on a Marko...

Pairwise rank based likelihood for estimating the relationship between two homogeneous populations and their mixture proportion

We consider the problem of inferring the relationship between two homogeneous populations, and the prevalence of each population. Sample data from the two distributions as well as from a third population consisting of a mixture of the two will be used. Under the transformation model assumption on the two distribution functions, we develop a pairwise rank based likelihood. Simultaneous inference...

An integrated method for estimating selectivities in a multidatabase system

A multidatabase system (MDBS) integrates information from autonomous local databases managed by diierent database management systems (MDBS) in a distributed environment. A number of challenges are raised for query optimization in such an MDBS. One of the major challenges is that some local optimization information may not be available at the global level. We recently proposed a query sampling m...

AN AMALGAMATED METHOD FOR ESTIMATING AGE-RELATED CENTILES